Evidence map›Paper›PMID 41416164›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Periodontitis Aggravates Chronic Obstructive Pulmonary Disease Progression by Promoting Pulmonary Macrophage M1 Polarizations].

Jing Li, Kaixin Xiong, Boyu Tang, Ziyi Xia, Zhao Tang, Yan Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jing Li（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.ORCID 0009-0001-9663-8177
Kaixin Xiong（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Boyu Tang（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Ziyi Xia（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Zhao Tang（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Yan Li（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-2323-8105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the critical role of macrophage M1 polarization in mediating the effect of periodontitis on the progression of chronic obstructive pulmonary disease (COPD). Methods: Alveolar lavage fluid samples were collected from COPD patients with comorbid periodontitis, and gene expression analysis was performed to validate the changes in the expression of M1 polarization-related genes. A mouse model of COPD, with experimentally induced periodontitis, were established. Hematoxylin and eosin (HE) staining of pathological sections was performed to observe the effect of periodontitis on COPD progression. Flow cytometry, immunofluorescence staining, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) were performed to analyze the effect of periodontitis on macrophage M1 polarization and the expression of relevant genes in the alveolar lavage fluid and lung tissues. Results: In clinical samples of alveolar lavage fluid from COPD patients with periodontitis, the expression of macrophage M1 polarization-related genes, including Conclusion: Periodontitis exacerbates COPD progression by promoting macrophage M1 polarization in the lungs. Enhancing oral hygiene management and targeting the inhibition of macrophage M1 polarization may represent new therapeutic strategies for the clinical prevention and control of COPD.

Indexed as

Macrophages, AlveolarPeriodontitisPulmonary Disease, Chronic ObstructiveAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedNitric Oxide Synthase Type IINitric Oxide Synthase Type IIChronic obstructive pulmonary diseaseM1 polarizationMacrophagesPeriodontitis

Identifiers

PMID41416164
PMCPMC12709074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.