ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Determination of 18 Perfluorinated Compounds in Tea Leaves by a Quick, Easy, Cheap, Effective, Rugged, and Safe Method Combined With Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To establish an analytical method for the simultaneous determination of 18 perfluoroalkyl compounds (PFCs) in tea leaves using a quick, easy, cheap, effective, rugged, and safe (QuEChERS) method for sample pretreatment combined with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Methods: The target analytes-18 PFCs-included 13 carboxylic acid PFCs (perfluorobutanoic acid [PFBA], perfluoropentanoic acid [PFPeA], perfluorohexanoic acid [PFHxA], perfluoroheptanoic acid [PFHpA], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], perfluorodecanoic acid [PFDA], perfluoroundecanoic acid [PFUdA], perfluorododecanoic acid [PFTrDA], perfluorotridecanoic acid [PFTeDA], perfluorotetradecanoic acid [PFHxDA], perfluorohexadecanoic acid [PFHpS], and perfluorooctadecanoic acid [PFODA]) and 5 sulfonic acid PFCs (perfluorobutanesulfonic acid [PFBS], perfluorohexanesulfonic acid [PFHxS], perfluoroheptanesulfonic acid [PFHpS], perfluorooctanesulfonic acid [PFOS], and perfluorodecanesulfonic acid [PFDS]). The QuEChERS pretreatment parameters were systematically optimized using the response surface methodology. The tea leave samples were extracted with an 80% acetonitrile solution and subsequently purified by adding a mixed absorbent consisting of 20 mg N-propyl-ethylenediamine (PSA), 210 mg graphitized carbon black GCB), and 60 mg octadecylsilane (C Results: Under the optimized conditions, the limits of detection (LODs) and limits of quantification (LOQs) of the method were 0.0057-1.23 ng/g and 0.019-4.09 ng/g, respectively. The average recoveries of most target compounds were 71.1%-117.9%, with relative standard deviations (RSDs) below 15%. The AGREE index of the method was 0.49, and the AES score was 76. At least one PFC was detected in each of the 132 tea leave samples, and the detection rate of carboxylic acid PFC was higher than that of sulfonic acid PFC. The highest detection rates were observed for PFBA at 97.74%, PFHpA at 93.23%, and PFOA at 92.24%. In contrast, PFHpS, PFUdA, PFDoA, PFHxDA, and PFODA were not detected in the samples. Conclusion: The proposed method has the advantages of simplicity, rapidity and sensitivity, and is suitable for the analysis of PFCs in tea leaves. The method has high greenness with minimal impact on the operator and the environment. The widespread presence of PFC contamination in tea leaves available in the market warrants strengthened monitoring and regulatory control.
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