Evidence map›Paper›PMID 41416139›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Inhibitory Effects of the Deep Underground Low Background Radiation Environment on the Proliferation and Migration of NP69 Human Nasopharyngeal Epithelial Cells and the Underlying Mechanisms].

Zhizhen Hao, Can Li, Ling Wang, Yuhao Zou, Jirui Wen, Jiang Wu, Xuehong Wan, Feng Liu, Jifeng Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhizhen Hao（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0002-6153-5562
Can Li（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Ling Wang（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Yuhao Zou（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Jirui Wen（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Jiang Wu（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-8434-5257
Xuehong Wan（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Feng Liu（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Jifeng Liu（ 610041） Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-9603-013X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effects of low background radiation environments in deep underground settings on the biological behavior of NP69 human nasopharyngeal epithelial cells (NP69 cells) and the underlying molecular mechanisms. Methods: A parallel control experimental design was adopted and NP69 cells were synchronously cultured in settings of three underground depths at the China Results: CCK-8 assay revealed that, after 72 h of culture, the absorbance value of the DeUFO-0 m group was 1.35 times and 1.27 times those of the those of the DeUFO-1000 m and DeUFO-1500 m groups, respectively (both Conclusion: The low background radiation environment in deep underground settings suppresses the proliferation and migration activities of NP69 cells by mediating ECM remodeling and post-transcriptional regulatory mechanisms through the regulation of target genes such as the CELF family. This study provides experimental evidence for establishing a dose-response relationship between environmental radiation and cellular effects.

Indexed as

Cell MovementCell ProliferationEpithelial CellsNasopharynxCell LineChinaHumansCell proliferation/migrationDeep underground medicineLow background radiation environmentNP69 human nasopharyngeal epithelial cellsTranscriptomics

Identifiers

PMID41416139
PMCPMC12709110

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