ArticleJournal of inflammation research2025
Variations in Platelet Count Associated with the Occurrence of Infected Pancreatic Necrosis, Surgical Intervention, and Mortality in Acute Pancreatitis: A Retrospective Cohort Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Platelet-Derived LGALS9 Suppresses NLRP3 Inflammasome-Dependent Pyroptosis in Pancreatic Acinar Cells During Severe Acute Pancreatitis.Journal of inflammation research · 2026Article
- Using the Phillygenin Ameliorates the Severe Acute Pancreatitis in Rats by Inhibiting TLR4/NF-κB Pathway.Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute pancreatitis (AP) is a common abdominal emergency, often associated with severe complications such as infected pancreatic necrosis (IPN) and the need for surgical intervention. Platelet count dynamics during the course of AP may be linked to disease progression and outcomes. Purpose: This study aimed to identify clinically meaningful longitudinal platelet count patterns in AP. Methods: Longitudinal platelet count patterns were derived using group-based trajectory modeling (GBTM). Generalized additive models were used to demonstrate the association between platelet counts and outcomes. Results: 2225 AP patients are enrolled in the analysis and classified into 5 subclasses using GBTM. Class 1 (n=269) had a low initial platelet count, which increased slowly; Class 2 (n=983) and Class 4 (n=597) had different initial platelet count levels, but fluctuated within the normal range; Class 3 (n=225) and Class 5 (n=151) had different initial platelet count levels, but both increased beyond the normal range. A significantly decreased risk of infected pancreatic necrosis (IPN) is observed in classes 2 (OR 0.3, CI 0.16-0.55) and 4 (OR 0.14, CI 0.06-0.33), but the risk was comparable among classes 1 (ref), 3 (OR 1.25, CI 0.66-2.41), and 5 (OR 0.69, CI 0.28-1.56). The risks of the surgical interventions were similar. However, the 30-day and 90-day mortality rates were significantly lower in classes 2, 3, 4, and 5 than in class 1. Generalized additive models also demonstrated the lowest risk of IPN, surgical intervention, and in-hospital mortality as platelet counts remained within the normal range. Conclusion: Patients with platelet counts within the normal range had the lowest risk of IPN, surgical intervention, and mortality. Both thrombocytopenia and thrombocytosis indicate an increased risk of IPN and surgical intervention; however, mortality is significantly increased only in patients with thrombocytopenia.
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