ArticleFood science & nutrition2025
Modifiable Dietary Habits, Inflammatory Mediation, and Senile Cataract: Unraveling Causality via Mendelian Randomization.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Causal effects of antibody-mediated immunity to pathogens on five ophthalmic diseases: a Mendelian randomization study.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Modifiable Dietary Habits, Inflammatory Mediation, and Senile Cataract: Unraveling Causality via Mendelian Randomization.Food science & nutrition · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senile cataract (SC) is a major cause of global vision impairment and blindness, posing a significant public health challenge in aging populations. This study employed Mendelian randomization (MR) using genetic instruments for 83 dietary habits from the UK Biobank GWAS, with SC data from the FinnGen R12 as the outcome. We employed multiple MR methods, including bidirectional MR, replication sample MR, and multivariable MR (MVMR), to identify dietary habits significantly associated with SC. The potential mediating effects of inflammatory biomarkers were further assessed using a two-step MR. Finally, to validate the core findings, additional analyses employed independent datasets for the overall cataract phenotype and the cataract surgical endpoint. After false discovery rate correction and validation in an independent cohort, meal-aligned alcohol consumption, compared to drinking apart from meals, demonstrated a substantial and robust protective causal effect against SC (OR = 0.67; 95% CI = 0.55-0.82;
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