Evidence map›Paper›PMID 41416088›Full record

ArticleFrontiers in medicine2025

Effects of oral and transdermal estrogen on postoperative endometrial recovery after missed abortion: a retrospective longitudinal cohort study.

Lushuang Zhang, Shiyang Liu, Yunyi Su, Liubiqi Zhao, Xiaoqin Gan, Xuan Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lushuang ZhangDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shiyang LiuDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yunyi SuDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Liubiqi ZhaoDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaoqin GanDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xuan DuanDepartment of Gynecology and Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Missed abortion is a common complication of early pregnancy, and surgical evacuation remains the primary treatment. This study aims to evaluate the effects of no estrogen, oral estrogen, and transdermal estrogen on postoperative endometrial recovery and long-term reproductive outcomes. Methods: This retrospective longitudinal cohort study included women with early missed abortion who underwent surgical evacuation at Chengdu Women's and Children's Central Hospital between June 2023 and May 2025. Patients were stratified into three groups: no-estrogen, oral estrogen, and transdermal estrogen. Clinical data were collected at five time points: perioperative period, 1 week postoperatively, 1 month postoperatively, 3 months postoperatively, and 1 year postoperatively. Primary outcomes were endometrial thickness, intrauterine adhesion, adverse reactions, and 1-year pregnancy outcomes. Statistical analyses comprised the Results: A total of 561 women were included. Endometrial thickness at 1 and 3 months was significantly greater in both estrogen groups compared with the no-estrogen group ( Conclusion: Postoperative estrogen therapy promotes endometrial recovery after the surgical treatment of missed abortion. Both oral and transdermal estrogen treatments were effective, but transdermal administration provided better tolerability and adherence. Estrogen use may improve reproductive prognosis, warranting further prospective studies to confirm these findings.

Indexed as

cohort studyestrogen therapymissed abortionoral estrogentransdermal estrogen

Identifiers

PMID41416088
PMCPMC12708237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.