ArticleFrontiers in endocrinology2025
Association of serum miR-99a level and metabolic dysfunction-associated steatotic liver disease, serum mTOR levels in patients with type 2 diabetes mellitus.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Purpose: This study was designed with the goal of exploring miR-99a expression in T2DM patients suffering from comorbid MASLD and clarifying the importance of miR-99a in this pathological context. Methods: A total of 137 subjects were included in this study, including 50 T2DM patients with MASLD (T2DM +MASLD group),48 T2DM patients without MASLD (T2DM group), and 39 healthy subjects (Control group). We measured the levels of IL-6, mTOR and SOD in the serum of the subjects by ELISA. The plasma miR-99a levels was detected by RT-PCR. The correlation between serum miR-99a level and other indicators was analyzed. Results: Serum miR-99a levels (median 0.79 vs 0.16 vs 0.03, Conclusions: These data highlight a potential role for miR-99a as a regulator of the comorbid incidence of T2DM and MASLD, suggesting that measuring the levels of miR-99a can effectively predict the risk of MASLD in those with T2DM.
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