Evidence map›Paper›PMID 41416039›Full record

Articlenpj health systems2025

Operationalizing a research-oriented learning healthcare system across covered entities: cross-institutional strategies and innovations.

Timothy R Huerta, Christopher W Bartlett, Gabriel Alain, Thomas Bentley, Carol R Bradford, John Fp Bridges, Arnab Chakravarti, Alexander A Farag, Cynthia A Gerhardt, Tyler Gorman and 19 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj health systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Timothy R Huerta *College of Medicine, The Ohio State University, Columbus, OH USA.
Christopher W Bartlett *Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH USA.
Gabriel AlainCollege of Medicine, The Ohio State University, Columbus, OH USA.
Thomas BentleyThe Ohio State University, Wexner Medical Center, Columbus, OH USA.
Carol R BradfordCollege of Medicine, The Ohio State University, Columbus, OH USA.
John Fp BridgesCollege of Medicine, The Ohio State University, Columbus, OH USA.
Arnab ChakravartiCollege of Medicine, The Ohio State University, Columbus, OH USA.
Alexander A FaragJacksonville Sinus Institute, Jacksonville, FL USA.
Cynthia A GerhardtAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH USA.
Tyler GormanAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH USA.
Shaun J GrannisSchool of Medicine, Indiana University, Indianapolis, IN USA.
Yungui HuangAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH USA.
Julie A JohnsonCollege of Medicine, The Ohio State University, Columbus, OH USA.
Nina V KraguljacCollege of Medicine, The Ohio State University, Columbus, OH USA.
Lang LiCollege of Medicine, The Ohio State University, Columbus, OH USA.
Qin MaCollege of Medicine, The Ohio State University, Columbus, OH USA.
Puneet MathurCollege of Medicine, The Ohio State University, Columbus, OH USA.
Marcy MaysCollege of Medicine, The Ohio State University, Columbus, OH USA.
Ann Scheck McAlearneyCollege of Medicine, The Ohio State University, Columbus, OH USA.
Eneida A MendoncaCincinnati Children's Hospital Medical Center, Cincinnati, OH USA.
Sayoko E MoroiCollege of Medicine, The Ohio State University, Columbus, OH USA.
Xia NingCollege of Medicine, The Ohio State University, Columbus, OH USA.
Colin OddenCollege of Medicine, The Ohio State University, Columbus, OH USA.
Lauren PhelpsCollege of Medicine, The Ohio State University, Columbus, OH USA.
William E SmoyerAbigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH USA.
Robert StrouseCollege of Medicine, The Ohio State University, Columbus, OH USA.
Curtis WalkerCollege of Medicine, The Ohio State University, Columbus, OH USA.
Ping ZhangCollege of Medicine, The Ohio State University, Columbus, OH USA.
Dukagjin M BlakajCollege of Medicine, The Ohio State University, Columbus, OH USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUM1TR004548 · NCATS · OHIO STATE UNIVERSITY · PI CYNTHIA A GERHARDT, JULIE A. JOHNSON · 2023 to 2026
$22.0M
NCATS NIH HHS UM1 TR004548
6 · The paper itself

Abstract

The concept of a Learning Health System (LHS) has been widely discussed in academic literature, yet its practical implementation remains a challenge. This paper describes the institutional journey, leadership structure, data governance policies, and technical innovations that together support a scalable and sustainable Research-Oriented LHS. Additionally, we propose an expanded data vision that aligns with interdisciplinary and translational research needs. Supplementary materials provide technical details for those interested in implementing such a model.

Indexed as

Business and industryHealth careMedical research

Identifiers

PMID41416039
PMCPMC12708347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.