Aesthetic Improvement, Facial Harmony, and Patient Satisfaction after Lower Face Treatment with a Hyaluronic Acid Filler: A Randomized Post-Marketing Study to Evaluate Two Different Stepwise Injection Approaches.

Steven H Dayan, Corey L Hartman, Carlo Di Gregorio, Luiz Avelar, Alessandra Haddad, Bill Andriopoulos, Torun Bromée

Abstract read

In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven H DayanDr. Dayan is with DeNova Research in Chicago, Illinois.

Corey L HartmanDr. Hartman is with Skin Wellness Dermatology in Homewood, Alabama.

Carlo Di GregorioDr. Di Gregorio is with a plastic surgery private practice in Palermo, Italy.

Luiz AvelarDr. Avelar is with Luiz Eduardo Avelar Cirurgia Plástica in Belo Horizonte, Brazil.

Alessandra HaddadDr. Haddad is with Hospital Israelita Albert Einstein in São Paulo, Brazil.

Bill AndriopoulosDr. Andriopoulos is with Galderma Laboratories in Dallas, Texas.

Torun BroméeDr. Bromée is with Galderma in Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe authors sought to evaluate a flexible, hyaluronic acid (HA) filler, Restylane® Defyne™ (HA

methodsHA

resultsBoth approaches achieved similar, favorable results at Week 9, with 100% of patients in both groups (Down-up, n=31; Top-down, n=29) demonstrating aesthetic improvement on the GAIS, improved skin firmness and facial harmony, and natural-looking results. Of patients seeking aesthetic improvement of the submental area, 95% in the Top-down group and 100% in the Down-up achieved improvement. Patient-reported endpoints supported these results, with high satisfaction throughout the study. HA LIMITATIONS: The results should be considered indicative rather than definitive given the post-marketing design of the study.

conclusionBoth stepwise approaches may be used for administering HA

Indexed as

chinhyaluronic acid fillerInjection approachmarionette linesnasolabial foldspatient satisfaction

Identifiers

PMID41416028

PMCPMC12710989

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.