ArticleFrontiers in bioengineering and biotechnology2025
Electrospun bioactive polymer biomaterials enriched with collagen and platelet-rich plasma as a platform for
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Growth factor-free chondrogenesis and immunomodulation of Wharton's jelly MSCs on chitosan-hyaluronic acid films.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Electrospun bioactive polymer biomaterials have gained increasing interest as platforms for cartilage tissue engineering due to their ability to mimic the extracellular matrix (ECM) and provide structural and biochemical support for mesenchymal stem cell (MSC) differentiation. The present study aimed to assess the influence of these bioactive compounds on the chondrogenic differentiation of MSCs. Methods: Poly(L-lactic acid) (PLA) fibrous mats were fabricated using electrospinning techniques, including standard and coaxial electrospinning, to incorporate bioactive components, namely collagen I and platelet-rich plasma (PRP). The wettability, the fibers diameter, degradation of the mats and PRP release profile were assessed. MSC differentiation culture was performed to determine the effect of the mats on the chondrogenic lineage. Results: The fabricated fibrous mats exhibited distinct morphological and physicochemical characteristics, with core-shell (CS) fibers demonstrating reduced diameters compared to pure PLA and PLA-collagen (Col) fibers. Wettability studies revealed that PRP encapsulation within the PLA shell did not alter the hydrophobic nature of the material, while the presence of collagen significantly enhanced its hydrophilicity. The PRP release profile from CS fibers exhibited a controlled release within the initial 3 days, followed by stabilization. Furthermore, MSC differentiation studies confirmed that both PRP and collagen-enriched fibrous mats supported chondrogenic differentiation over 14-day period, with Col mats demonstrating the highest glycosaminoglycan (GAG) production. The presence of aggrecan, a key chondrogenic marker, was most pronounced on collagen mats and comparable or lower on PRP (CS) compared with PLA, particularly at 14 days. Discussion: Furthermore, the observations revealed the presence of two critical markers of cartilage differentiation: namely, actin cytoskeletal reorganization and depolymerization. The presented findings highlight the potential of bioactive PLA fibrous mats enriched with PRP and collagen I as promising platforms for cartilage tissue regeneration. The combination of electrospinning techniques enables tailored fiber structures that support chondrogenesis, offering a potential alternative for tissue engineering applications.
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