ReviewJournal of biological methods2025
Genetic and stem cell insights into the pathogenesis of endometriosis: A comprehensive review.
Review in Journal of biological methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Epigenetics, Oxidative Stress, and the Microbiome in Endometriosis: Toward an Integrated Mechanistic Framework for Precision Medicine.Journal of personalized medicine · 2026Review
- Immune mechanisms in the pathogenesis of endometriosis: a comprehensive analysis of the role of NK cells, cytokines, and extracellular vesicles/exosomes.Frontiers in immunology · 2026Review
- GREB1 as a Context-Dependent Molecular Switch in Endometrial Estrogen-Progesterone Crosstalk: From Physiological Receptivity to Endometriosis Pathogenesis-A Narrative Review.International journal of women's health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis represents a predominant gynecological disease that globally impacts 10% of women in their reproductive years, often leading to pelvic pain, infertility, and other complications. Objective: This review intended to impart a comprehensive understanding of the pathophysiology, inherent genetic susceptibility, and the role of stem cells in the progression of endometriosis. It explores the diagnostic challenges posed by the diverse presentation of lesions and the involvement of genetic factors, including genes related to inflammation, immune response, steroidogenesis, neo-angiogenesis, and DNA repair. In addition, the role of adult stem cells, particularly from bone marrow and the endometrium is highlighted as an important aspect of disease progression. The review also examined how environmental factors, including early menarche, heavy menstrual flow, and Müllerian anomalies, contribute to endometriosis development. The impact on fertility is discussed concerning pelvic anatomical distortions, which affect egg release, sperm motility, and embryo transit. Furthermore, the review addressed complications, such as chronic pelvic pain, dysmenorrhea, dyspareunia, and potential obstetric issues, including an increased risk of certain cancers. Finally, it emphasized the need for improved diagnostic techniques and targeted therapies, focusing on early detection, innovative treatments, and fertility preservation. Conclusion: Advancements in genomic and molecular research are crucial to understanding the genetic basis of endometriosis and ultimately enhance the quality of life for those affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.