ArticleFrontiers in nutrition2025
Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Responsiveness to nutrients can be determined by many types of variations, such as single-nucleotide polymorphisms (SNPs). Choline is an essential nutrient critical for proper organ function and exists in different forms, such as free choline or as derivatives, including phosphatidylcholine (PC). Although genetic variations in genes encoding enzymes that influence choline metabolism have been identified, little is known regarding individual responses to free choline and PC in relation to SNPs. Here, we determined the effect of different forms of choline, genotype, and their interaction on one-carbon metabolite concentrations in urine, which has utility in capturing the overall change in choline metabolism. Methods: A randomized, double-blinded, crossover study was conducted in healthy adult males ( Results: There was a main treatment effect for urinary choline change from baseline, reflective of differences in absorption by free choline versus PC ( Conclusion: Unique metabolite signatures in one-carbon metabolism arise in response to supplemental intake of different forms of choline, driven by genetic variations that regulate choline homeostasis. Our findings highlight the importance of nutrient-gene interactions in deciphering the complexity of individual metabolic responses, supporting the emerging concept of precision nutrition.
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