Evidence map›Paper›PMID 41415794›Full record

ArticleIndian journal of surgical oncology2025

Additional Risk Factors Lead to a Measurable Inflammatory Response in Stage I Endometrial Cancer-A Prospective Multicentric Observational Study.

Carlo Ronsini, Irene Iavarone, Maria Giovanna Vastarella, Luigi Della Corte, Giada Andreoli, Giuseppe Bifulco, Luigi Cobellis, Pasquale de Franciscis

Registry-linked trialAbstract read
In one paragraph

Article in Indian journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05657483 (Inflammatory Index as a Predictor for Endometrial Cancer), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05657483 unknown statusnot on this map

Inflammatory Index as a Predictor for Endometrial Cancer: an Observational Study

TypeobservationalSponsorUniversity of Campania Luigi VanvitelliRan2022 to 2024Enrolled128ConditionsEndometrial Neoplasms, Inflammatory ResponseArmsVenous blood sample, Surgical staging of endometrial cancer
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo RonsiniDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.ORCID 0000-0002-9023-282X
Irene IavaroneDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.
Maria Giovanna VastarellaDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.
Luigi Della CorteDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples, 80138 Naples, Italy.
Giada AndreoliDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.
Giuseppe BifulcoDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples, 80138 Naples, Italy.
Luigi CobellisDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.
Pasquale de FranciscisDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Largo Madonna Delle Grazie, 1-80138 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the study is to explore the correlation between inflammation indices (NLR, MLR, PLR) and prognostic factors (myometrial infiltration, LVSI, grading) in FIGO 2023 stage I endometrial carcinoma. From August 2023 to March 2024, a prospective study was conducted on 163 women diagnosed with stage I endometrial cancer. The research methods were established a priori and authorized through evaluation by the Ethics Committee of the individual centers (IRB 30661/2022 of 31/03/2022). The study was then registered on the clinicaltrials.gov platform under NCT05657483. Blood samples were collected preoperatively to measure the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR). Histopathological data on myometrial infiltration, LVSI, and grading were also analyzed. NLR values were 2.07, 2.35, and 2.68 for no infiltration, < 50%, and ≥ 50% myometrial infiltration, respectively (

Indexed as

DiagnosisEndometrial carcinomaInflammation indicesLymphovascular space invasion (LVSI)Myometrial infiltration

Identifiers

PMID41415794
PMCPMC12708463

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.