ArticleJournal of the Korean Society of Radiology2025
Leptomeningeal Enhancement Manifesting as a Treatment-Related Change in Isocitrate Dehydrogenase-Wildtype Glioblastoma Mimicking Leptomeningeal Metastases on Contrast-Enhanced FLAIR MRI: A Case Report.
Article in Journal of the Korean Society of Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leptomeningeal metastases in isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM) is crucial for determining patient prognosis and treatment plans. Advancements in surgical techniques and concurrent chemoradiotherapy have increased the survival time of patients, resulting in a higher detection rate of leptomeningeal metastases. Evaluation of leptomeningeal metastasis status has traditionally relied on brain MRI, particularly contrast-enhanced T1-weighted images. However, the increasingly used contrast-enhanced fluid attenuated inversion recovery (FLAIR) imaging has demonstrated superior performance in diagnosing leptomeningeal tumor metastases and detecting other lesions. We present a case of leptomeningeal enhancement that regressed on subsequent follow-up without any treatment changes. This condition may be more frequently accounted for when using contrast-enhanced FLAIR.
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