Evidence map›Paper›PMID 41415579›Full record

ArticleFrontiers in pharmacology2025

T817MA attenuates oxidative stress and ER stress via the HSP70-HSP90 pathway after brain ischemia

Tao Wang, Ya-Juan Pan, Mei-Mei Zhang, Xuan Wang, Wei Li, Jian-Meng Lv

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tao WangDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Ya-Juan PanDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Mei-Mei ZhangDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Xuan WangDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Wei LiDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Jian-Meng LvDepartment of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke imposes a substantial global burden, with oxidative stress and endoplasmic reticulum (ER) stress being the pivotal pathological mechanisms. Heat shock proteins (HSPs), especially HSP70 and HSP90, play critical roles in neuroprotection against ischemic injury. In this study, we investigate the neuroprotective effects of T817MA, a novel compound, and its underlying mechanisms

Indexed as

endoplasmic reticulum stressHSP70HSP90oxidative stressstrokeT817MA

Identifiers

PMID41415579
PMCPMC12708517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.