ArticlebioRxiv : the preprint server for biology2025
Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes.
Milad Ahmed, Joshua Carlson, Asima Das, Syeda Farjana Hoque, Joshua B Benoit, Miguel A Chiurillo, Noelia Lander
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Milad AhmedDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
Joshua CarlsonDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
Asima DasDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
Syeda Farjana HoqueDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.ORCID 0000-0002-4018-3513 Miguel A ChiurilloDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.
Noelia LanderDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-006, United States of America.ORCID 0000-0003-2178-381X Funding
Mosquito hydration status as a mechanism that alters pre-feeding host interactions and post-feeding physiologyR01AI148551 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., XIAO, YANYU · 2020 to 2024
$2.1MLarge-scale CRISPR screening of essential calcium-related genes in the human parasite Tr. cruziR00AI137322 · NIAID · UNIVERSITY OF CINCINNATI · PI LANDER, NOELIA · 2021 to 2022
$498kBarcode screening of essential protein kinases in the life cycle progression of Trypanosoma cruziR21AI178573 · NIAID · UNIVERSITY OF CINCINNATI · PI CHIURILLO, MIGUEL A · 2023 to 2024
$446kCharacterization of cAMP signaling microdomains in the human pathogen Trypanosoma cruziR21AI182544 · NIAID · UNIVERSITY OF CINCINNATI · PI LANDER, NOELIA · 2025 to 2025
$445kInfluence of sleep-like states on mosquito behavior and physiologyR21AI166633 · NIAID · UNIVERSITY OF CINCINNATI · PI BENOIT, JOSH B., VINAUGER, CLEMENT · 2022 to 2023
$429kAmerican Heart Association-American Stroke Association 23IPA1054779NIAID NIH HHS R00 AI137322NIAID NIH HHS R01 AI148551NIAID NIH HHS R21 AI166633NIAID NIH HHS R21 AI178573NIAID NIH HHS R21 AI182544
6 · The paper itselfAbstract
Cyclic AMP (cAMP) signaling is crucial for environmental sensing and response to stress conditions in trypanosomatids. However, the mechanisms driving the specificity of cAMP signals remain poorly understood in these protozoan parasites. We recently identified two putative cAMP microdomains in
Indexed as
cAMP microdomainsChagas diseaseContractile vacuole complexFlagellar distal domainKissing bugsMetacyclogenesisOsmoregulationPhosphodiesterases
Identifiers
PMID41415456
PMCPMC12710649
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