Evidence map›Paper›PMID 41415453›Full record

ArticlebioRxiv : the preprint server for biology2025

Nanopore sequencing reveals operon-specific ribosome remodeling accompanying naphthyridone resistance in

Dionysius W Copoulos, Kelly T Hughes, Fabienne F Chevance, Cynthia J Burrows, Aaron M Fleming, Ryan E Looper

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dionysius W CopoulosDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, United States.
Kelly T HughesSchool of Biological Sciences, University of Utah, Salt Lake City, UT, 84112-0850, United States.
Fabienne F ChevanceSchool of Biological Sciences, University of Utah, Salt Lake City, UT, 84112-0850, United States.
Cynthia J BurrowsDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, United States.
Aaron M FlemingDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, United States.
Ryan E LooperDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, United States.

Funding

Pd-Catalyzed Olefin Functionalization Reactions for Organic SynthesisR01GM063540 · NIGMS · UNIVERSITY OF UTAH · PI SIGMAN, MATTHEW S · 2002 to 2019
$5.3M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR017539 · NCRR · UNIVERSITY OF UTAH · PI PUGMIRE, RONALD J · 2003 to 2003
$3.8M
Chemical Modifications in Regulatory Regions of DNA and RNAR35GM145237 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Cynthia J Burrows · 2022 to 2026
$2.3M
Development of Selective Ribosomal P-site InhibitorsR01AI127724 · NIAID · UNIVERSITY OF UTAH · PI LOOPER, RYAN EDWARD · 2017 to 2020
$1.5M
A 500MHz NMR Spectrometer with AutomationS10OD025241 · OD · UNIVERSITY OF UTAH · PI FLYNN, PETER F · 2018 to 2018
$600k
From genomics to natural language processing: A protected environment for research computing in the health scienceS10OD021644 · OD · UNIVERSITY OF UTAH · PI CHEATHAM, THOMAS E. · 2017 to 2017
$494k
NCRR NIH HHS C06 RR017539NIAID NIH HHS R01 AI127724NIGMS NIH HHS R01 GM063540NIGMS NIH HHS R35 GM145237NIH HHS S10 OD021644NIH HHS S10 OD025241
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) threatens global health; however, the molecular adaptations underlying resistance to emerging antibiotic classes remain poorly defined. Here, we applied long-read DNA and direct RNA nanopore sequencing and developed methods to deconvolute operon-specific epitranscriptomic changes. Together, this platform uncovered a previously unrecognized, operon-specific pathway of resistance in

Identifiers

PMID41415453
PMCPMC12710958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.