Evidence map›Paper›PMID 41415445›Full record

ArticlebioRxiv : the preprint server for biology2025

A human sensory neuron model for varicella-zoster virus latency and reactivation

Alexander C Havelaar, Joseph S Flot, Saori Fukuda, Anja W M de Jong, R I Koning, Amber Schotting, Sem van 't Geloof, Tomohiko Sadaoka, Georges M G M Verjans, Paul R Kinchington and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander C HavelaarHerpeslabNL, Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Joseph S FlotDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Saori FukudaDivision of Virus Persistence & Dynamics, Center for Infectious Disease Research, Research Promotion Headquarters, Fujita Health University, Aichi, Japan.
Anja W M de JongElectron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
R I KoningElectron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Amber SchottingHerpeslabNL, Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Sem van 't GeloofHerpeslabNL, Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Tomohiko SadaokaDivision of Virus Persistence & Dynamics, Center for Infectious Disease Research, Research Promotion Headquarters, Fujita Health University, Aichi, Japan.
Georges M G M VerjansHerpeslabNL, Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0002-2465-2674
Paul R KinchingtonDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1901-9970
Werner J D OuwendijkHerpeslabNL, Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0001-8393-296X

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Role of VZV Latency Transcript (VLT) and ORF63 in latency and reactivationR01AI151290 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINCHINGTON, PAUL R., VERJANS, GEORGES MICHEL · 2021 to 2025
$3.5M
VZV vaccine attenuation and the DNA damage responseR01AI158510 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Paul R. Kinchington · 2022 to 2026
$3.2M
NEI NIH HHS P30 EY008098NIAID NIH HHS R01 AI151290NIAID NIH HHS R01 AI158510
6 · The paper itself

Abstract

Varicella-zoster virus (VZV) is a ubiquitous human neurotropic alphaherpesvirus that establishes lifelong latency in sensory ganglionic neurons. Subsequent viral reactivation causes herpes zoster, a morbid disease often complicated by neuropathic pain. Mechanisms underlying VZV latency and reactivation are not understood, mostly due to the lack of permissive animal models and challenges of current

Identifiers

PMID41415445
PMCPMC12710762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.