Evidence map›Paper›PMID 41415424›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct cellular and transcriptional mechanisms mediate an antioxidant therapeutic response in 22q11-deleted upper layer cortical projection neurons.

Shah Rukh, Daniel W Meechan, Abra Roberts, Connor Siggins, Zachary D Erwin, Thomas M Maynard, Anthony-S LaMantia

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Shah RukhCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.ORCID 0000-0001-7424-6386
Daniel W MeechanCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.ORCID 0009-0005-6258-6566
Abra RobertsCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.
Connor SigginsCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.ORCID 0009-0002-3970-792X
Zachary D ErwinCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.
Thomas M MaynardCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.ORCID 0000-0001-6976-3936
Anthony-S LaMantiaCenter for Neurobiology Research, The Fralin Biomedical Research Institute at Virginia Tech-Carilion School of Medicine.ORCID 0000-0002-9458-5534

Funding

Regulation of 22q11 Genes in Embryonic and Adult ForebrainR01HD042182 · NICHD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ANTHONY S LAMANTIA · 2003 to 2026
$8.6M
Targeting Mitochondrial Function to Develop Novel Therapies for Neurodevelopmental DisordersR21MH126294 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LAMANTIA, ANTHONY S · 2021 to 2022
$440k
NICHD NIH HHS R01 HD042182NIMH NIH HHS R21 MH126294
6 · The paper itself

Abstract

We characterized cellular and molecular mechanisms underlying the therapeutic response

Identifiers

PMID41415424
PMCPMC12710829

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.