Evidence map›Paper›PMID 41415420›Full record

ArticlebioRxiv : the preprint server for biology2025

Amyloid-mediated RNA uptake by sperm for embryonic delivery.

William S Mallen, Nataliya Zabello, Susan Brenner-Morton, Simone Sidoli, Isabella D Pirozzolo, Feng-Xia Liang, Joseph Sall, Jason Yin, Priyanka Mathews, Guoan Zhang and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William S MallenMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.ORCID 0000-0003-3981-9702
Nataliya ZabelloMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Susan Brenner-MortonMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-9073-6641
Isabella D PirozzoloMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.ORCID 0000-0003-0025-8549
Feng-Xia LiangMicroscopy Laboratory, New York University Grossman School of Medicine, New York, NY 10016, USA.
Joseph SallMicroscopy Laboratory, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-8585-175X
Jason YinMicroscopy Laboratory, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0009-0006-8637-3423
Priyanka MathewsMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Guoan ZhangProteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10065, USA.
Carolyn L LeeMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Anthony W P FitzpatrickMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-3527-7961

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Orbitrap Exploris 480 Basic SystemS10OD030286 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIDOLI, SIMONE · 2021 to 2021
$600k
NCI NIH HHS P30 CA016087NIH HHS S10 OD030286
6 · The paper itself

Abstract

Seminal fluid RNA is essential for embryonic development, but the mechanism by which extracellular RNA is transferred from seminal fluid to sperm remains unclear. Here, we identify a role for functional amyloid fibrils in seminal fluid that bind and traffic RNA to mammalian sperm and, upon fertilization, the zygote. We show that highly cationic peptides in seminal fluid phase separate with RNA to form amyloid fibrils. Cryo-electron tomography reveals that these amyloid fibrils are internalized by sperm. Furthermore, biophysical and

Identifiers

PMID41415420
PMCPMC12709466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.