Evidence map›Paper›PMID 41415405›Full record

ArticlebioRxiv : the preprint server for biology2025

Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid models.

Shashi Kant Tiwari, Gulshanbir Baidwan, Samantha Trescott, Shweta Jakhmola, Nicole G Coufal, Tariq M Rana

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shashi Kant TiwariDepartment of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Gulshanbir BaidwanDepartment of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Samantha TrescottDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Shweta JakhmolaDepartment of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Nicole G CoufalDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Tariq M RanaDepartment of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

Funding

Revealing the single cell determinants of brain relevant to persistent HIV infection and opioid use disorderU01DA053630 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2021 to 2025
$11.2M
Single cell determinants of brain in the context of viral persistence in SIV/cART/cocaine non-human primatesU01DA058402 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shilpa J Buch, TARIQ M RANA · 2023 to 2026
$9.9M
Investigating the molecular mechanisms of HIV/AIDS associated neurological disorders using microglia and cerebral organoids derived from induced pluripotent stem cellsR01DA049524 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2019 to 2023
$3.9M
NIDA NIH HHS R01 DA049524NIDA NIH HHS U01 DA053630NIDA NIH HHS U01 DA058402
6 · The paper itself

Abstract

HIV-associated neurocognitive disorder (HAND) is characterized by glial activation and neuroinflammation emerging from HIV infection. Moreover, methamphetamine (METH) is a highly addictive psychostimulant whose use is linked to high HIV prevalence, significantly worsening clinical outcomes for people living with HIV and hastening onset of systemic illness. Overall, pathologies associated with HIV infection/METH use comorbidity include neuroinflammation, neurotoxicity, synaptodendritic damage, and resulting cognitive dysfunction. However, mechanisms underlying this neuropathogenesis remain elusive due to the scarcity of human brain-specific experimental model systems. Therefore, we created a next-generation three-dimensional (3D) human brain model derived from human induced pluripotent stem cells (hiPSCs). Specifically, this 3D

Indexed as

3D cerebral organoidsCNS damage by HIVhuman microgliaiPS cellsmethamphetamine effects on brain and HIV

Identifiers

PMID41415405
PMCPMC12709470

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.