Evidence map›Paper›PMID 41415393›Full record

ArticlebioRxiv : the preprint server for biology2025

Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus.

Julia E Dziabis, Irene O Jonathan, Benjamin L Horvath, Grace Zhang, Michael S Patton, Caroline J Smith, Dang M Nguyen, Mahika Jammula, Benjamin A Devlin, S K Monroe and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julia E DziabisDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0002-2886-9192
Irene O JonathanDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Benjamin L HorvathDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Grace ZhangDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Michael S PattonDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0001-9218-3315
Caroline J SmithDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Dang M NguyenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Mahika JammulaDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Benjamin A DevlinDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0003-0174-547X
S K MonroeDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Erica J FreemanDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
A Brayan Campos-SalazarDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Madeline J ClarkDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Staci D BilboDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID 0000-0001-6736-7841

Funding

5/11 Microglial MyD88 in Mouse Models of Excessive Alcohol IntakeU01AA029969 · NIAAA · DUKE UNIVERSITY · PI Staci D Bilbo · 2022 to 2026
$2.0M
A novel role for developmental microglial-parvalbumin interneuron interactions in adult alcohol drinking behavior.F31AA030712 · NIAAA · DUKE UNIVERSITY · PI DZIABIS, JULIA · 2022 to 2024
$127k
NIAAA NIH HHS F31 AA030712NIAAA NIH HHS U01 AA029969
6 · The paper itself

Abstract

Parvalbumin interneurons (PVIs) are disrupted across diverse neurodevelopmental disorders, highlighting their vulnerability to developmental perturbations. Inflammation can perturb PVI development and function, and inflammatory mechanisms are often propagated within the brain by microglia. Yet the microglial mechanisms linking inflammatory signals to interneuron development are unclear. To test the role of microglial innate immune signaling in PVI development, we used mice lacking toll-like receptor adaptor MyD88 specifically in microglia. MyD88-deficient microglia showed reduced inflammatory responses but increased early-life phagocytosis of inhibitory synaptic material. In adulthood, males without microglial MyD88 exhibited increased hippocampal PVI density, increased extracellular matrix (ECM) deposition, increased inhibitory signaling, and impaired discrimination behaviors. We determined the cytokine interleukin (IL)-33, which normally drives adult microglial remodeling of the ECM, is developmentally regulated in the hippocampus. MyD88-deficient microglia fail to respond to IL-33, leading to reduced remodeling of the ECM component aggrecan. These results reveal microglial immune signaling via MyD88 regulates hippocampal inhibitory circuit development in a sex-specific manner.

Identifiers

PMID41415393
PMCPMC12709473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.