Evidence map›Paper›PMID 41415361›Full record

ArticlebioRxiv : the preprint server for biology2025

LocusPackRat: a Semi-Automated Framework for Prioritizing Candidate Genes from Large GWAS Intervals.

Brian Gural, Todd Kimball, Anh N Luu, Christoph D Rau

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Brian GuralDepartment of Genetics, University of North Carolina at Chapel Hill.
Todd KimballDepartment of Genetics, University of North Carolina at Chapel Hill.ORCID 0000-0002-4032-3141
Anh N LuuComputational Medicine Program, University of North Carolina at Chapel Hill.ORCID 0000-0002-8216-7271
Christoph D RauDepartment of Genetics, University of North Carolina at Chapel Hill.ORCID 0000-0002-0782-207X

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
Elucidating the Role of Multinuclearity in Healthy and Diseased Mammalian CardiomyocytesR01HL162636 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christoph Daniel Rau · 2023 to 2026
$1.9M
Discovery of Novel Epigenetic Regulators of Heart Failure in a Panel of MiceR00HL138301 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAU, CHRISTOPH DANIEL · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL138301NHLBI NIH HHS R01 HL162636NHLBI NIH HHS T32 HL069768
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) routinely implicate broad loci that span tens of megabases and contain dozens of genes, making the leap from locus to causal gene challenging, especially in model organism cohorts with reduced mapping resolution. We developed LocusPackRat, a semi-automated, easily extendible package that assembles standardized 'packets' of evidence to accelerate candidate gene prioritization. Each packet merges study-specific information for each gene in a locus such as differential expression between conditions or presence of

Indexed as

Candidate Gene PrioritizationCollaborative CrossGWASInterMinePrioritization AlgorithmR

Identifiers

PMID41415361
PMCPMC12710630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.