ArticleAmerican journal of translational research2025
Levothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for differentiated thyroid carcinoma.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the efficacy of levothyroxine (L-T4) suppression therapy in women with a history of differentiated thyroid carcinoma (DTC), focusing on pregnancy outcome after thyroidectomy.
methodsThis retrospective study included 300 pregnancies in women with previous DTC surgery. Participants were divided into an experimental group (n=187) receiving L-T4 doses adjusted based on thyroid-stimulating hormone (TSH) levels and a control group (n=113) following a fixed low-dose L-T4 regimen. We assessed various outcomes, including biochemical values (TSH dynamics, lipid profile, folic acid [FA] levels), obstetric measures (placental function, pregnancy complications), and neonatal outcomes.
resultsThe experimental group showed consistently lower TSH levels throughout pregnancy and experienced fewer pregnancy and neonatal complications compared to the control group (all P<0.05). Additionally, the experimental group demonstrated significant improvements in lipid profiles, FA levels, and placental function(all P<0.05).
conclusionsTSH-adjusted L-T4 therapy in pregnant women post-DTC thyroidectomy results in better maternal and neonatal outcomes compared to a fixed low-dose L-T4 regimen. This approach optimizes TSH stability, improves lipid and FA profiles, and enhances placental function, leading to improved overall outcomes for both the mother and child.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.