ArticleAmerican journal of translational research2025
Diagnostic value of macrophage inflammatory protein-1α, plasma thrombomodulin, and interleukin 12 in stroke-associated infections.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the levels of macrophage inflammatory protein-1α (MIP-1α), plasma thrombomodulin (PTM), and interleukin-12 (IL-12) in the peripheral blood of patients with stroke-associated infections (SAIs) and clarify their correlation with secondary nosocomial infection.
methodsClinical data from 75 patients with acute ischemic stroke (AIS) complicated by SAIs admitted between January 2022 and October 2024 were retrospectively analyzed as the infected group. Another 60 AIS patients without infection during the same period were selected as the uninfected group. Peripheral blood levels of MIP-1α, PTM, and IL-12 were measured, and their correlation with secondary nosocomial infection was evaluated.
resultsPearson correlation analysis showed that serum MIP-1α, PTM, and IL-12 levels were positively correlated with inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), procalcitonin, and IL-6 in the infected group (all
conclusionPatients with SAIs exhibited elevated serum levels of MIP-1α, IL-12, and PTM, demonstrating significant diagnostic value for stroke-associated infection.
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