ArticleAmerican journal of translational research2025
Long-term efficacy of adalimumab in elderly patients with rheumatoid arthritis and associated risk factors.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the long-term efficacy of adalimumab (ADA) combined with methotrexate (MTX) in elderly patients with rheumatoid arthritis (RA) and to identify risk factors associated with therapeutic efficacy.
methodsThis retrospective study enrolled 320 RA patients aged ≥60 years, divided into a control group (MTX monotherapy, n=157) and a combination group (MTX plus ADA, n=163), with a 24-month follow-up. Primary endpoints included improvements in disease activity and functional status, while secondary endpoints comprised changes in inflammatory markers and safety outcomes. Multivariate regression analysis was conducted to determine predictors of efficacy.
resultsThe overall response rate was significantly higher in the combination group than that in the control group (P<0.05). After 24 months, reductions in Disease Activity Score (DAS) in 28 joints based on erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and tumor necrosis factor-α were all significantly greater in the combination group (all P<0.001). Combination therapy markedly reduced the risk of treatment failure (odds ratio [OR]=0.296, P=0.001). High baseline disease activity (DAS in 28 joints based on CRP≥5.1, OR=2.568) and elevated ESR (≥40 mm/h, OR=1.082) were independent predictors of poor efficacy. Injection-site reactions occurred more frequently in the combination group (P<0.05).
conclusionADA combined with MTX significantly improves disease activity and functional outcomes in elderly patients with RA, demonstrating sustained long-term efficacy and acceptable safety. For patients with a high baseline inflammatory burden, combination therapy should be prioritized, with individualized management guided by risk stratification.
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