ArticleFrontiers in molecular biosciences2025
Exploring the interaction mechanisms of CD46/TREM1 and LC3B/ATG5 in the inflammation-cancer transformation of oral squamous cell carcinoma based on bioinformatics.
Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling.International dental journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the molecular interaction patterns between CD46/TREM1 and LC3B/ATG5 in the development of oral squamous cell carcinoma (OSCC), providing novel targets for elucidating the mechanism of inflammatory-to-cancer progression and for the early diagnosis and treatment of OSCC. Methods: An oral inflammation-to-cancer progression animal model was established using 4-Nitroquinoline-N-oxide (4-NQO) drinking water and/or lipopolysaccharide (LPS). Clinical oral leukoplakia (OLK), OSCC, and adjacent non-cancerous tissues were collected. Immunohistochemistry assessed CD46, TREM1, LC3B, ATG5 protein expression and PI3K-AKT/TNF pathway alterations in animal and clinical tissues. Enzyme-Linked Immunosorbent Assay (ELISA) measured inflammatory cytokine levels in serum and saliva. High-throughput sequencing analyzed key pathways. Results: Immunohistochemistry revealed elevated CD46/TREM1 expression and reduced LC3B/ATG5 expression in OSCC tissues ( Conclusion: CD46 and TREM1 are highly expressed in OSCC and serve as key initiating factors in the progression from OLK to OSCC. Bioinformatics analysis identified critical candidate genes (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.