Evidence map›Paper›PMID 41415019›Full record

ArticleRespirology case reports2025

Economic Impact of Biologics for Severe Asthma: A Case Series of 14 Patients From Northern Malaysia.

Arvindran Alaga, Izzatul Nadzirah Ismail

Abstract read
In one paragraph

Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arvindran AlagaRespiratory Department Hospital Sultanah Bahiyah Alor Setar Kedah Malaysia.ORCID https://orcid.org/0000-0003-4873-1999
Izzatul Nadzirah IsmailRespiratory Department Hospital Sultanah Bahiyah Alor Setar Kedah Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There remains a paucity of evidence from Asia on the cost-effectiveness of biologics for severe asthma. This pilot cost-offset analysis aims to evaluate the economic impact of adding biologics (omalizumab or benralizumab) to severe asthma standard care as a proof of concept for its cost-effectiveness, and to assess improvement in exacerbation rates and asthma control. Fourteen patients from the Severe Asthma Registry of Hospital Sultanah Bahiyah, Kedah who received biologics for at least 12 months from January 2018 to December 2024 were included. The economic impact of biologic treatment was evaluated by comparing the cost of biologic administration with the potential savings from reduced exacerbations requiring emergency department visits and hospital admission. Cost savings were observed with biologics, alongside reduced exacerbation and improved asthma control in real-world settings. Future research could explore a full cost-effectiveness analysis and a budget impact analysis to inform strategic pricing and reimbursement decisions.

Indexed as

benralizumabbiologicseconomic evaluationomalizumabsevere asthma

Identifiers

PMID41415019
PMCPMC12710096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.