Evidence map›Paper›PMID 41414904›Full record

ArticleGut microbes2026

Attenuating ETEC virulence using a heat-labile enterotoxin-blocking binding protein.

Marcus Petersson, Jens Sivkær Pettersen, Helena Bay Henriksen, Ágnes Duzs, Monica L Fernández-Quintero, Nick Jean Burlet, Natalia Mojica, Ute Krengel, Timothy P Jenkins, Andrew B Ward and 5 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marcus PeterssonDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-2466-9038
Jens Sivkær PettersenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-0293-6692
Helena Bay HenriksenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
Ágnes DuzsBactolife A/S, Copenhagen, Denmark.ORCID 0000-0001-6176-3149
Monica L Fernández-QuinteroDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-6811-6283
Nick Jean BurletDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0009-0002-5099-3971
Natalia MojicaDepartment of Chemistry, University of Oslo, Oslo, Norway.
Ute KrengelDepartment of Chemistry, University of Oslo, Oslo, Norway.ORCID 0000-0001-6688-8151
Timothy P JenkinsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0003-2979-5663
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, USA.ORCID 0000-0001-7153-3769
Thomas Emil AndersenDepartment of Clinical Microbiology, Odense University Hospitaland the Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-9453-1141
Jakob Møller-JensenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-6008-3771
Lone GramDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0002-1076-5723
Andreas Hougaard LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.ORCID 0000-0001-6918-5574
Sandra Wingaard ThraneBactolife A/S, Copenhagen, Denmark.ORCID 0000-0003-2098-2710

Funding

Wellcome Trust
6 · The paper itself

Abstract

Bacterial enteric pathogens are major contributors to the global burden of diarrheal diseases and the associated consequences for human health including malnutrition, growth stunting, morbidity, and mortality. While mortality from diarrhea has decreased, incidence remains high, and better interventions for preventing disease are needed. Single-domain antibodies (i.e., V

Indexed as

Bacterial ToxinsEnterotoxigenic Escherichia coliEnterotoxinsEscherichia coli InfectionsEscherichia coli ProteinsSingle-Domain AntibodiesCholera ToxinHumansProtein BindingVirulenceBacterial ToxinsCholera ToxinEnterotoxinsEscherichia coli Proteinsheat-labile enterotoxin, E coliSingle-Domain Antibodiesbinding proteinscholera toxinEnterotoxigenic Escherichia coligastrointestinal infectionsheat-labile enterotoxininfection modelsingle-domain antibodyVibrio cholerae

Identifiers

PMID41414904
PMCPMC12754688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.