ArticleAnimal bioscience2026
Genome-wide association study dissection of candidate genes for fleece traits in Inner Mongolia cashmere goats based on whole-genome resequencing data.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveGenome-wide association study (GWAS) and haplotype analysis were employed to identify molecular markers and candidate genes associated with fleece traits in Inner Mongolia cashmere goats (IMCGs).
methodsGWASs using whole-genome resequencing data together with phenotypic data from 2,299 IMCGs, applying four models: mixed linear model, multiple locus mixed linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway. We focused on the GWAS signals to conduct gene annotation and performed functional enrichment analyses to explore the biological processes underlying these signals. Additionally, haplotypes were constructed for the significant loci, and haplotype-phenotype association analyses were performed to identify molecular markers and candidate genes associated with these fleece traits in IMCGs.
resultsWe identified 542 SNPs and 179 candidate genes linked to fleece traits through GWAS and gene annotation. Genes such as LAMA3, KCTD1, PTK7, FGFR3, LEF1, TAPT1, PTCH1, ELOVL6, and EVC have emerged as important candidates that may influence fleece traits. Furthermore, 11 haplotype blocks related to fleece traits were constructed, among which A1A1, C1C1, E2E2, F1F1, G1G1, H1H1 and K1K1 were identified as the superior haplotype combinations for fleece traits. These could serve as important molecular markers to improve the accuracy of early selection and the economic efficiency of breeding programs for fleece traits in IMCGs.
conclusionThis study successfully employed GWAS to identify key genetic loci significantly associated with the fleece traits of IMCGs. The genetic basis of these traits was revealed through additional gene annotation and haplotype analysis. The findings provide important theoretical and practical foundations for molecular breeding in IMCGs.
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