Trial reportIntegrative cancer therapies
Efficacy of Exercise on Severity of Paclitaxel-Induced Peripheral Neuropathy and Improving Quality of Life in Women with Non-metastatic Breast Cancer: Results of an Interim Analysis from an Ongoing Randomized Clinical Trial (ExPIN Trial).
Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundPaclitaxel-induced peripheral neuropathy (PIPN) is a dose-limiting adverse effect during paclitaxel therapy, with no effective treatment and often incomplete recovery. This study assessed the effects of exercise on PIPN severity in newly diagnosed advanced breast cancer patients.
methodsThe ExPIN Trial is an ongoing randomized clinical trial. This interim analysis, conducted between November 2022 and December 2023, included adult patients with locally advanced, non-metastatic breast cancer. Participants were randomized into interventional and control groups for 0 to 12 weeks. The primary outcome was nerve conduction studies. Secondary outcomes included balance scores, taxane-induced toxicity-related quality-of-life scores, emotional functioning, physical functioning, and functional impairments assessed at baseline, after chemotherapy, and at the first follow-up.
resultsSeventy patients were randomized. The mean (SD) age was 49.46 (9.52) years in the interventional group and 49.09 (8.10) years in the control group. At the completion of paclitaxel therapy, the amplitudes of the ulnar nerve (estimate: 1.98,
conclusionsExercise intervention during paclitaxel therapy significantly reduced PIPN severity and improved quality of life. Findings are preliminary and warrant further confirmation.
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