Evidence map›Paper›PMID 41414745›Full record

ArticleJournal of the International AIDS Society2025

A call to action to advance global research priorities related to Undetectable = Untransmittable.

Sarah K Calabrese, Jacob Bor, Mandisa Dukashe, David A Kalwicz, Kennedy Mupeli, Dorina Onoya, Lucy Stackpool-Moore, Bruce Richman

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah K CalabreseDepartment of Psychological and Brain Sciences, George Washington University, Washington, DC, USA.ORCID https://orcid.org/0000-0003-2640-0208
Jacob BorDepartment of Global Health, Boston University, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5112-8536
Mandisa DukasheSouth African National AIDS Council, Pretoria, South Africa.
David A KalwiczDepartment of Psychological and Brain Sciences, George Washington University, Washington, DC, USA.ORCID https://orcid.org/0000-0002-4616-3898
Kennedy MupeliCentre for Youth of Hope, Gaborone, Botswana.
Dorina OnoyaHealth Economics and Epidemiology Research Office, University of Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-2664-7342
Lucy Stackpool-MooreWatipa, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9862-5564
Bruce RichmanPrevention Access Campaign, New York, New York, USA.ORCID https://orcid.org/0000-0001-5908-8623

Funding

Integrating U=U into HIV counseling: a cluster-randomized efficacy trial (INTUIT 2.0)R01MH135774 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Jacob Bor, Dorina Onoya · 2024 to 2026
$1.8M
NIMH NIH HHS R01 MH135774
6 · The paper itself

Abstract

introductionThe Undetectable = Untransmittable (U = U) message has failed to reach many people living with HIV (PLHIV) and their communities despite evidence of its favourable impacts. DISCUSSION: We describe and contextualize six global research priorities related to U = U, which focus on: (1) examining the effects of U = U messaging on health and economic outcomes; (2) illuminating and addressing barriers to U = U communication among healthcare providers, policymakers and other stakeholders; (3) expanding U = U research to include all key populations disproportionately affected by HIV; (4) addressing limited and inequitable access to information and resources; (5) determining how to optimally communicate about U = U in the context of evolving scientific knowledge and guidelines; and (6) collaborating on parallel studies across countries to improve comparability of study findings and identify cross-cultural differences.

conclusionsFuture research targeting these six priorities is needed to guide effective messaging about U = U in healthcare settings and public health programmes throughout the world. Ultimately, bridging existing gaps in U = U awareness, understanding and acceptance can enable PLHIV and others to reap the benefits associated with this valuable message.

Indexed as

HIV InfectionsResearchGlobal HealthHumansHIVkey and vulnerable populationspublic healthtreatmentTreatment as PreventionUndetectable = Untransmittable

Identifiers

PMID41414745
PMCPMC12715337

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.