ArticleInfection control and hospital epidemiology2026
Risk factors for progression from
Article in Infection control and hospital epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
objectiveTo identify host and clinical risk factors contributing to the development of
designRetrospective, matched case-control study.
settingDuke University Health System, including 3 hospitals and affiliated outpatient clinics.
participantsAdult patients who underwent ≥2 two-step
methodsData collection encompassed a 90-day "pre-exposure" period preceding index testing and a ≤ 90-day "exposure" period between index and repeat testing. Antibiotic use was stratified by risk for each period. Multivariate conditional logistic regression with forward selection was used to identify predictors of progression.
resultsAmong 2,212 colonized patients, 71 cases and 133 matched controls were identified. Several host and clinical characteristics were independently associated with progression to CDI in our multivariate model. Notably, high-risk antibiotic use across the pre-exposure and exposure periods was associated with greater odds of progression to CDI compared to other patterns of antibiotic use (adjusted odds ratio 2.70;
conclusionsSustained exposure to high-risk antibiotics was a strong predictor of the progression from
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