Evidence map›Paper›PMID 41414698›Full record

ArticleACS synthetic biology2026

Ribozyme-Enabled Tissue Specificity (RETS): A System for Precise Gene Expression without Specialized Promoters.

Max M Combest, Josh Conlin, Vivia Van De Mark, Morgan Boisen, Hadley Colwell, Arjun Khakhar

Abstract read
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Max M CombestDepartment of Biology, Colorado State University, Fort Collins, Colorado 80523, United States.
Josh ConlinDepartment of Biology, Colorado State University, Fort Collins, Colorado 80523, United States.
Vivia Van De MarkWalter Scott Jr. College of Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.
Morgan BoisenDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, United States.
Hadley ColwellDepartment of Biology, Colorado State University, Fort Collins, Colorado 80523, United States.
Arjun KhakharDepartment of Biology, Colorado State University, Fort Collins, Colorado 80523, United States.ORCID 0000-0002-4676-6533

Funding

Elucidating Mechanisms and Design Principles for Chemically Inducible Expression ModulationR35GM155313 · NIGMS · COLORADO STATE UNIVERSITY · PI Arjun Khakhar · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM155313
6 · The paper itself

Abstract

Tissue- or cell-type-specific expression of transgenes is often essential for interrogation of the biological phenomenon or predictable engineering of multicellular organisms but can be stymied by cryptic enhancers that make identification of promoters that generate desired expression profiles challenging. In plants, the months-to-years long timeline associated with prototyping putative tissue-specific promoters in transgenic lines deepens this challenge. We have developed a novel strategy called Ribozyme-Enabled Tissue

Indexed as

RNA, CatalyticArabidopsisGene Expression Regulation, PlantIntronsOrgan SpecificityPlants, Genetically ModifiedPromoter Regions, GeneticRNA, MessengerTetrahymena thermophilaTransgenesRNA, CatalyticRNA, Messengerexpression biosensorplant developmentplant synthetic biologyribozymestissue-specific expression

Identifiers

PMID41414698
PMCPMC12997588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.