ArticleAngewandte Chemie (International ed. in English)2026
Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
The direct transformation of simple and abundant feedstocks into structurally complex molecules remains a central challenge in modern organic synthesis. Herein, we report a method for the oxidative cascade cyclization of N-aryl and N-benzoyl acrylamide derivatives, promoted by methane and other gaseous alkanes. This transformation is enabled by a readily available iron catalyst in combination with N-fluorobenzenesulfonimide (NFSI) as the oxidant, proceeding under mild conditions to afford a diverse array of N-heterocyclic frameworks in high yields. Late-stage functionalization studies highlight the utility of methane in the synthesis of biologically relevant scaffolds. Moreover, the Fe/NFSI system facilitates a radical sampling regime that enables the selective functionalization of less reactive primary C─H bonds. Overall, this work establishes a sustainable and versatile platform for constructing molecular complexity directly from gaseous alkanes.
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Registered trials
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