Evidence map›Paper›PMID 41413913›Full record

Observational studyCritical care (London, England)2025

Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis.

Antoine Kimmoun, Nicolas Girerd, Kevin Duarte, Jolie Bruno, Jimmy Schenk, Bruno Levy, Guillaume Baudry, Senta Jorinde Raasveld, Sanne de Bruin, Merijn C Reuland and 39 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Antoine KimmounUniversité de Lorraine, CHRU de Nancy, Service de Médecine Intensive et Réanimation Brabois, INSERM U116, DCAC, Nancy, France. akimmoun@gmail.com.
Nicolas GirerdUniversité de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy F-CRIN INI-CRCT, Nancy, France.
Kevin DuarteUniversité de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy F-CRIN INI-CRCT, Nancy, France.
Jolie BrunoUniversité Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Jimmy SchenkDepartment of Epidemiology and Data Science, Amsterdam University Medical Centre, Amsterdam Public Health, University of Amsterdam, Amsterdam, the Netherlands.
Bruno LevyUniversité de Lorraine, CHRU de Nancy, Service de Médecine Intensive et Réanimation Brabois, INSERM U116, DCAC, Nancy, France.
Guillaume BaudryUniversité de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy F-CRIN INI-CRCT, Nancy, France.
Senta Jorinde RaasveldDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Sanne de BruinDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Merijn C ReulandDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Claudia van den OordDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Caroline M SchaapDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jan BakkerDepartment of Intensive Care Adults, Erasmus MC University Medical Centers, Rotterdam, the Netherlands.
Maurizio CecconiDepartment of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.
Aarne FeldheiserDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, EvangKliniken Essen-Mitte, Huyssens-Stiftung/Knappschaft, Essen, Germany.
Jens MeierDepartment of Anesthesiology and Intensive Care, Kepler University Clinic, Kepler University, Linz, Austria.
Zoe McQuiltenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Marcella C A MüllerDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Thomas W L ScheerenDepartment of Anesthesiology, University Medical Center Groningen, Groningen, the Netherlands.
Cécile AubronMédecine Intensive Réanimation, CHU de Brest, Université de Bretagne Occidentale, Brest, France.
Andrew W J FlintSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Tarikul HamidDepartment of Critical Care, Asgar Ali Hospital, Dhaka, Bangladesh.
Michaël PiagnerelliDepartment of Intensive Care, CHU Charleroi Marie Curie, Université Libre de Brussels, Charleroi, Belgium.
Tina Tomić MahečićDepartment of Anesthesiology and Intensive Care, University Clinical Hospital Center Zagreb, Zagreb, Croatia.
Jan BenesDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Faculty of Medicine Plzen-Charles University, Plzen, Czech Republic.
Lene RussellDepartment of Intensive Care, Copenhagen University Hospital, Rigshospitalet Copenhagen, Copenhagen, Denmark.
Hernan Aguirre-BermeoUnidad de Cuidados Intensivos, Hospital Vicente Corral Moscoso, Cuenca, Ecuador.
Konstantina TriantafyllopoulouDepartment of Cardiothoracic Surgery, European Interbalkan Medical Center, Thessaloniki, Greece.
Vasiliki ChantziaraIntensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Chest Hospital, Athens, Greece.
Mohan GurjarDepartment of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Sheila Nainan MyatraDepartment of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Vincenzo PotaDepartment of Child, General and Specialistic Surgery, University of Campania, Luigi Vanvitelli, Naples, Italy.
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Ryszard GawdaDepartment of Anesthesiology and Intensive Care, Institute of Medical Sciences, University of Opole, Opole, Poland.
Mafalda MouriscoDepartment of Intensive Care, Centro Hospitalar de Entro O Douro E Vouga, Santa Maria da Feira, Portugal.
Marcus LanceDepartment of Anesthesiology, Aga Khan University Hospital, Nairobi, Kenya.
Vojislava NeskovicDepartment of Anesthesia and Intensive Care, Military Medical Academy Belgrade, Belgrade, Serbia.
Matej PodbregarMedical Faculty Ljubljana, University of Ljubljana, General Teaching Hospital Celje, Ljubljana, Slovenia.
Juan V LlauDepartment of Anesthesiology and Post-Surgical Critical Care, University Hospital Doctor Peset, Valencia, Spain.
Manual Quintana-DiazIntensive Care Service, Hospital Universitario La Paz, Madrid, Spain.
Maria CronhjortDepartment of Clinical Science and Education, Karolinska Institutet, SödersjukhusetStockholm, Sweden.
Carmen A PfortmuellerDepartment of Intensive Care, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Nihan YapiciDepartment of Anesthesiology and Reanimation, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, University of Health Sciences, Istanbul, Turkey.
Nathan NielsenDivision of Pulmonary, Critical Care and Sleep Medicine, Section of Transfusion Medicine and Therapeutic Pathology, University of New Mexico School of Medicine, Albuquerque, USA.
Akshay ShahNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Harm-Jan de GroothDepartment of Epidemiology and Data Science, Amsterdam University Medical Centre, Amsterdam Public Health, University of Amsterdam, Amsterdam, the Netherlands.
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Alexandre MebazaaUniversité Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
InPUT study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRed-blood-cell (RBC) transfusion is one of the most frequent interventions in critical care patients. While patients with acute cardiac conditions are more likely to receive transfusions at higher haemoglobin thresholds than other critically ill patients, data on RBC transfusion practice for critically ill patients with pre-existing cardiac conditions are scarce.

methodsUsing the International Point-Prevalence Study of Intensive-Care Unit Transfusion Practices cohort, weighted logistic regression investigated the association between the RBC units transfused and the primary composite outcome of 28-day mortality, new-onset acute kidney injury or ventilatory weaning failure. Interactions with cardiac history (acute coronary syndrome and/or heart failure) were tested.

resultsCardiac history was present in 746 of 3643 patients (20%) and 894 of 3643 (25%) received at least one RBC unit. Transfusion rates were similar in patients with and without cardiac history (25% vs. 24%; p = 0.51). Among transfused patients, median nadir haemoglobin during ICU stay was slightly higher in those with cardiac history (7.6 g/dL vs. 7.4 g/dL respectively; p = 0.007), whereas stated haemoglobin transfusion threshold did not statistically differ (8.5 g/dL vs. 8.0 g/dL; p = 0.11). Each additional RBC unit increased the odds of the composite outcome in the whole cohort (2.18, 95% CI 1.85–2.56, p < 0.0001), without interaction with cardiac history (p = 0.44).

conclusionsRBC transfusion was commonly and similarly prescribed in critically ill patients with or without cardiac history. Each additional unit was associated with a worse outcome with no evidence of differential effect due to cardiac history.

trial registrationNL9049 (Dutch Trial Register), registered on 16 November 2020.

Indexed as

Erythrocyte TransfusionAgedCohort StudiesCritical IllnessFemaleHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedTreatment OutcomeCritical careHeart failureIntensive care unitsRed blood cell transfusion

Identifiers

PMID41413913
PMCPMC12713240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.