Evidence map›Paper›PMID 41413789›Full record

ArticleJournal of gynecologic oncology2026

Association of homologous recombination repair gene mutation with clinical prognosis in histological subtypes of epithelial ovarian cancer patients.

Yen-Han Wang, Heng-Cheng Hsu, Po-Han Lin, Kuan-Ting Kuo, Yi-Jou Tai, Chia-Ying Wu, Ying-Cheng Chiang

Abstract read
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In one paragraph

Article in Journal of gynecologic oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yen-Han WangGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0009-0001-9363-3055
Heng-Cheng HsuGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-6817-0693
Po-Han LinGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-6066-398X
Kuan-Ting KuoDepartment of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-3657-1652
Yi-Jou TaiDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1442-0850
Chia-Ying WuDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-9431-5916
Ying-Cheng ChiangDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.ORCID https://orcid.org/0000-0002-8958-5222

Funding

National Taiwan University Hospital 110-S4934National Taiwan University Hospital 111-S0006National Taiwan University Hospital 111-X0006National Taiwan University Hospital 113-S0122
6 · The paper itself

Abstract

objectiveTo investigate the associations of homologous recombination repair (HRR) gene mutations with clinical prognosis in epithelial ovarian cancer (EOC) patients with various histological subtypes.

methodsThe EOC patients treated at our institute from January 2014 to March 2021 were included. Gene mutations were detected using 24 target HRR genes. The associations between HRR gene mutations and clinical outcomes were analyzed.

resultsA total of 318 patients were evaluated, 37 patients had

conclusionHRR gene mutations were associated with platinum sensitivity, PARPi response and favorable survival in serous EOC patients. In non-serous EOC, HRR gene mutations did not show the same trend, which warrants further investigation.

Indexed as

Carcinoma, Ovarian EpithelialMutationOvarian NeoplasmsRecombinational DNA RepairAdultAgedCytoreduction Surgical ProceduresFemaleHumansMiddle AgedNeoplasm StagingPrognosisEpithelial Ovarian CancerHistological SubtypesHomologous Recombination Repair GenesPAPRi

Identifiers

PMID41413789
PMCPMC13226087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.