Observational studyRheumatology international2025
Increased transient elastography-derived liver stiffness in fibrotic interstitial lung disease compared with healthy controls and its association with high-resolution computed tomography extent: a cross-sectional observational study.
Observational study in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionFibrotic interstitial lung diseases are chronic diffuse parenchymal disorders characterised by progressive scarring and substantial morbidity. Transient elastography-derived liver stiffness is an established non-invasive marker of hepatic fibrosis, but it is unclear whether this liver-focused measurement carries any signal related to fibrotic interstitial lung disease. To assess, in a cross-sectional observational cohort, whether liver stiffness (LS) measured by transient elastography (TE) discriminates individuals with interstitial lung disease (ILD) from healthy controls and relates to HRCT-based disease burden, and to explore in-sample an empirical cut-point with pre-specified sensitivity analyses.
methods65 patients with ILD and 60 age- and sex-matched healthy controls underwent LS assessment using FibroScan
resultsMedian LS was significantly higher in ILD patients than in controls (4.90 vs. 2.98 kPa; p < 0.001). ROC analysis yielded an area under the curve of 0.867 for LS in predicting ILD, with a cut-off of 3.88 kPa (sensitivity, 76.9%; specificity, 85.0%). Non-CTD-ILD patients exhibited greater LS than CTD-ILD patients (6.5 vs. 4.6 kPa; p = 0.009). Within the CTD-ILD subgroup, only age correlated with LS (r = 0.402; p = 0.012). An LS ≥ 7.0 kPa was associated with a usual interstitial pneumonia pattern in 72.2% of cases, and advanced fibrosis (F3) was more frequent in non-CTD-ILD (p = 0.023).
conclusionsIn this cross-sectional cohort, TE-derived liver stiffness shows in-sample discriminatory ability and aligns with HRCT involvement, indicating a candidate biomarker signal; prognostic use is unproven and warrants adequately powered longitudinal validation.
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