Evidence map›Paper›PMID 41413642›Full record

ArticleScientific reports2025

Impact of 85 kHz versus 125 kHz SHIFT OCTA scan speeds on image quality in retinal diseases and diagnostic reliability of choroidal neovascular membranes.

Melanie D Tran, Nehal Nailesh Mehta, Ines D Nagel, Mohamed S Morsy, Amr L Ali, Anna Heinke, Ruby Munoz, Dirk-Uwe Bartsch, Evan Walker, Lingyun Cheng and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melanie D TranJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Nehal Nailesh MehtaJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Ines D NagelJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Mohamed S MorsyJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Amr L AliJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Anna HeinkeJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Ruby MunozJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Dirk-Uwe BartschJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Evan WalkerJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
Lingyun ChengJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA.
William R FreemanJacobs Retina Center, Shiley Eye Institute, University of California San Diego, 9415 Campus Point Dr, La Jolla, CA, 92093, USA. wrfreeman@health.ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Radha Ayyagari · 2012 to 2026
$10.3M
SCH: Multimodal Retina Image Alignment and ApplicationsR01EY033847 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AN, CHEOLHONG, BARTSCH, DIRK-UWE G · 2021 to 2024
$1.2M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY033847NIH HHS 5R01EY033847University of California-San Diego P30EY022589
6 · The paper itself

Abstract

The purpose of the study was to compare Optical Coherence Tomography Angiography (OCTA) scan speeds of 85 kHz and 125 kHz with respect to image quality, diagnostic reliability, and scan time in patients with retinal diseases. In this prospective cohort study, OCTA images were obtained at both scan speeds in 70 eyes from 40 patients with retinal diseases. Masked expert graders evaluated qualitative parameters including clinical utility, artifacts, and overall image quality. Quantitative parameters including scan time, Heidelberg Q-score, and OCTA-Q score were recorded. In 46 eyes with visible choroidal neovascular membrane in the avascular layer of OCTA, AngioTool (Image J) was used to assess vessel percentage area, vessel junction density, average vessel length, and E-Lacunarity. Acquisition speed of 125 kHz OCTA was significantly faster than that of 85 kHz. There were no statistically significant differences in AngioTool parameters between the two protocols. 125 kHz was significantly better than 85 kHz for image quality with fewer noise artefacts and vessel projection artefacts. In conclusion, 125 kHz SHIFT OCTA offers comparable to better image quality to the 85 kHz OCTA with significantly faster acquisition, potentially improving clinical workflow without compromising diagnostic reliability.

Indexed as

Choroidal NeovascularizationRetinal DiseasesTomography, Optical CoherenceAdultAgedAged, 80 and overArtifactsFemaleFluorescein AngiographyHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsAngiotoolHeidelberg spectralisOCTASHIFT OCTA

Identifiers

PMID41413642
PMCPMC12823581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.