ArticleTrials2025
Effect of pain science education administered condensed or longitudinally associated with manual therapy and exercises on pain intensity and disability for Temporomandibular Disorders: a randomized controlled trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06259344 (Effect of Pain Science Education Administered in Full or Fractioned Dosage Modes Associated With Conventional Treatment on Pain Intensity and Disability for Temporomandibular Disorders), which is not on this map. Not yet cited in PubMed.
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Effect of Pain Science Education Administered in Full or Fractioned Dosage Modes Associated With Conventional Treatment on Pain Intensity and Disability for Temporomandibular Disorders: a Randomized Controlled Trial
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTemporomandibular Disorders (TMD) are musculoskeletal disorders that affect the chewing structures and has a complex and multifactorial etiology. A biopsychosocial approach is recommended for the management of these disorders considering the multifactorial nature of TMD etiology. The aim of this study is to compare the effect of condensed Pain Science Education (PSE) program (2 initial sessions of 75 min) versus longitudinally administered PSE (6 sessions of 25 min) combined with manual therapy and neck motor control exercises (NMCE) on primary outcomes-pain intensity and disability-and secondary outcomes - mandibular range of motion, pain self-efficacy, fear of movement, global perceived effect of improvement, empathy, knowledge about pain neuroscience, beliefs about pain, exercise adherence, and pain catastrophizing-in patients with painful TMD.
methodsThis study will be a randomized controlled trial with a sample of 148 participants. Participants will undergo a screening process to identify TMD according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), aged 20 to 60 years, of both sexes, and then the volunteers will be randomized into two groups (G1: Condensed PSE + Manual therapy/orofacial and NMCE vs. G2: Longitudinal PSE + Manual therapy/orofacial and NMCE). The exercise intervention will take place once a week for 8 weeks, conducted by a physiotherapist, with each session lasting 1 h. The interventions will be administered by trained care providers. The primary outcomes will be pain intensity and disability, assessed using the numeric pain rating scale and the Craniofacial Pain and Disability Inventory (CF-PDI), respectively. For statistical analysis, a linear mixed models considering time and groups as factors will be used. A significance level of p < 0.05 will be considered. DISCUSSION: To date, no randomized controlled trial has yet been conducted to compare the effect of different modes of PSE delivery on pain intensity and disability in patients with painful chronic TMD.
trial registrationNCT06259344. Registered on February 14, 2024. https://classic. CLINICALTRIALS: gov/ct2/show/NCT06259344.
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