ArticleBMC gastroenterology2025
"Noninvasive predictive marker for esophageal variceal bleeding".
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Albumin-to-creatinine ratio as non-invasive marker for prediction of non- bleeding esophageal varices. a cross-sectional observational study.BMC gastroenterology · 2026Observational
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEsophageal varices are common in cirrhosis with portal hypertension; some patients face high risk of life-threatening esophageal variceal bleeding (EVB). Because few noninvasive markers predict EVB, this study sought to identify accessible predictors.
methodsFrom 2002 to 2018, 336 patients with high-risk or hemorrhagic esophageal varices were studied: 72 with recent variceal rupture/bleeding (EVB) and 264 without (EVNB). The study evaluated associations between EVB and several clinical scores and biomarkers, focusing on sarcopenia, Controlling Nutritional Status (CONUT) score, and neutrophil-to-lymphocyte ratio (NLR), alongside established indices.
resultsComparisons and univariate analyses were performed for MELD, CONUT, sarcopenia, fibrosis index, FIB-4, AST/ALT ratio, ALBI, and APRI between EVB and EVNB groups. Multivariate analysis identified the Neutrophil/Lymphocyte ratio (NLR) and CONUT score were identified as independent predictors associated with EVB. The CONUT score and NLR achieved AUROCs values were 0.75 and 0.65, with optimal cut-offs at 4.5 and 3.87, respectively. Notably, 58/72 (80.6%) EVB patients had CONUT > 4.5 and 31/72 (43.1%) had NLR > 3.87.
conclusionsComparing several noninvasive biomarkers and scoring systems, the study suggests CONUT ≥ 4.5 and NLR ≥ 3.87 as potential predictors of esophageal variceal bleeding. Because CONUT and NLR are routinely available and showed acceptable predictive performance, they may be practical tools for risk stratification in patients at risk for EVB.
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