Evidence map›Paper›PMID 41413450›Full record

ArticleBMC genomics2025

Exploring transmission dynamics in epidemiologically linked pulmonary tuberculosis cases and household contacts: a WGS-based investigation.

Getachew Seid, Andrea Maurizio Cabibbe, Betselot Zerihun, Ayinalem Alemu, Getu Diriba, Gemechu Tadesse, Wilber Sabiiti, Kiarash Moghaddasi, Ilaria Iannucci, Daniela Maria Cirillo and 3 more

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

13 authors.

Getachew SeidEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia. gech1365@gmail.com.
Andrea Maurizio CabibbeEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Betselot ZerihunEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia.
Ayinalem AlemuEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia.
Getu DiribaEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia.
Gemechu TadesseEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia.
Wilber SabiitiDivision of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, KY16 9TF, UK.
Kiarash MoghaddasiEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ilaria IannucciEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela Maria CirilloEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Saro AbdelaEthiopian Public Health Institute, P.o.box 1242, Addis Ababa, Ethiopia.
Solomon H MariamAklilu Lemma Institute of Pathobiology, Addis Ababa University, Po. Box 1176, Addis Ababa, Ethiopia.
Balako GumiAklilu Lemma Institute of Pathobiology, Addis Ababa University, Po. Box 1176, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genotyping of the M. tuberculosis complex has significantly enhanced the comprehension of transmission dynamics and is employed to substantiate transmission dynamics among epidemiologically interconnected cases. This investigation sought to examine genomic diversity, transmission dynamics, and mutations conferring drug resistance in epidemiologically linked pulmonary tuberculosis cases and their household contacts in central Ethiopia.

methodsA total of 50 genomes were considered for WGS analysis using the TB- profiler pipeline for drug resistance and genotypic analysis (SNP distance cut-off 12).

resultsBy analyzing the successful WGS data from 48 isolates, we identified that the majority were classified under lineages L4 (Euro-American, 33/48; 68.75%) and L3 (Delhi-CAS, 12/48; 25.0%). The Euro-American sub-lineage (L.4.2.2) was the most common (16/48; 33.33%). The incidence of tuberculosis due to M. bovis was 4.17% (2/48). Approximately one-fifth of the 48 isolates were determined to be at least MDR TB (10/48; 20.83%). The cluster analysis uncovered 4 clusters, resulting in an overall clustering rate of 17.02% (8 /47). Out of the four clusters, three were from the same household, while one cluster was from non-index household contacts. Out of the 10 index-HHC pairs that had valid WGS analysis, three exhibited genomes that were exactly matched.

conclusionPeople living in regions with a significant prevalence of tuberculosis face the danger of acquiring the disease from external sources. Genomic sequencing provides valuable information about the epidemiological trends of tuberculosis, which helps in developing improved strategies for high-risk groups susceptible to unnoticed TB transmission.

Indexed as

Mycobacterium tuberculosisTuberculosis, PulmonaryWhole Genome SequencingAdolescentAdultChildEthiopiaFamily CharacteristicsFemaleGenome, BacterialGenotypeHumansMaleMiddle AgedPhylogenyPolymorphism, Single NucleotideGenotype diversityHousehold contactIndex casePulmonary TBTransmission dynamics

Identifiers

PMID41413450
PMCPMC12828947

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