ArticleBMC microbiology2025
In vitro and in vivo exploration of microbiome-derived yeast extract for anti-aging and skin rejuvenation.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study.International journal of molecular sciences · 2026Trial
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin aging, a multifactorial process driven by intrinsic and extrinsic factors, results in diminished hydration, elasticity, and increased wrinkle formation. Yeast extract, particularly from Saccharomyces cerevisiae (S. cerevisiae), is rich in bioactive compounds with potential anti-aging properties, but its effect via oral administration remains underexplored.
objectiveTo evaluate the anti-aging efficacy of glutathione-enriched S. cerevisiae yeast extract in a photoaging-induced mouse model and human skin cell lines, including fibroblasts and keratinocytes, focusing on its molecular mechanisms.
methodsIn vitro studies were conducted using human dermal fibroblasts and keratinocytes to assess antioxidant activities of yeast extract (SOD and GPx), inflammatory markers (IL-1β, IL-6, TNF-α, and COX-2), and effects on aging-associated factors such as collagen, elastin, hyaluronic acid production and matrix metalloproteinase (MMP), collagenase, elastase, hyaluronidase activities. For in vivo studies, SKH-1 hairless mice were exposed to UVB irradiation to induce photoaging and orally administered yeast extract at various doses. Skin improvements were evaluated through measurements of hydration, trans-epidermal water loss (TEWL), elasticity, collagen fiber density, roughness, and epidermal thickness.
resultsThe yeast extract exhibited significant anti-aging effects in both in vitro and in vivo models. In vitro, it upregulated collagen and elastin synthesis, enhanced hyaluronic acid content, promoted antioxidant enzymes, and lessened inflammatory markers. Additionally, key dermal degradation factors, including MMP, elastase, collagenase, and hyaluronidase, were significantly downregulated. In vivo, oral administration improved skin hydration, TEWL, elasticity, and collagen fiber density, while visibly reducing wrinkle depth and roughness. Histological analysis further confirmed decreased epidermal thickness and increased collagen deposition, highlighting the extract’s potential in skin rejuvenation.
conclusionsGlutathione-enriched S. cerevisiae yeast extract showed substantial promise as a multifunctional anti-aging agent. It enhanced skin hydration, reduced oxidative stress, mitigated inflammation, and improved structural integrity, offering a comprehensive approach to combat skin aging.
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