Evidence map›Paper›PMID 41413441›Full record

ArticleBMC genomics2025

Genetics of range expansion and admixture of Aedes aegypti populations in California.

Melina Campos, Yoosook Lee, Katherine Brisco, Marc Crepeau, Anthony J Cornel, Gregory C Lanzaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melina CamposDepartment of Pathology, Microbiology and Immunology, Vector Genetics Laboratory, UC Davis, Davis, CA, USA.
Yoosook LeeDepartment of Entomology and Nematology, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Katherine BriscoDepartment of Entomology and Nematology, Mosquito Control Research Laboratory, University of California, Parlier, CA, USA.
Marc CrepeauDepartment of Pathology, Microbiology and Immunology, Vector Genetics Laboratory, UC Davis, Davis, CA, USA.
Anthony J CornelDepartment of Pathology, Microbiology and Immunology, Vector Genetics Laboratory, UC Davis, Davis, CA, USA.
Gregory C LanzaroDepartment of Pathology, Microbiology and Immunology, Vector Genetics Laboratory, UC Davis, Davis, CA, USA. gclanzaro@ucdavis.edu.

Funding

Dispersal biology of invasive Aedes aegypti mosquito populationsR35GM156217 · NIGMS · UNIVERSITY OF FLORIDA · PI Yoosook Lee · 2025 to 2026
$658k
NCEZID CDC HHS U01 CK000516NCEZID CDC HHS U01 CK000649NIGMS NIH HHS R35 GM156217NIH HHS R35GM156217Pacific Southwest Regional Center of Excellence for Vector-Borne Diseases, the U.S. Centers for Disease Control and Prevention 1U01CK000516Southern IPM Center working group grant as part of the National Institute of Food and Agriculture (NIFA) Crop Protection and Pest Management Regional Coordination Program 2022-70006-38002USDA National Institute of Food and Agriculture multi-state Hatch Project 7007941
6 · The paper itself

Abstract

backgroundThe mosquito Aedes aegypti, a key vector for arboviruses including dengue, Zika, and chikungunya, was first detected in California in 2013 and has since expanded northward. This study examines the genetic structure of California populations and, based on that structure, proposes potential mechanisms driving their invasion across the state.

resultsA whole-genome analysis of 181 individuals, including 49 newly sequenced from recently established populations in Northern California, corroborates previously described genetic structure and reveals the origins of these populations. Many northern populations shared ancestry with Southern California populations, suggesting passive dispersal. Additionally, we observed significant genetic admixture between divergent clusters in the Central Valley, associated with increased nucleotide diversity, which may enhance adaptive potential. We describe the effects of range expansion and genetic admixture on divergent ancestral lineages and discuss the importance of human-mediated dispersal in the spread of this invasive species.

conclusionsOur results illustrate the utility of genomic tools in surveillance programs for tracking dispersal patterns. Such strategies can contribute to mitigating the growing public health threat posed by Ae. aegypti's continued expansion in California, particularly as locally acquired arbovirus cases increase.

Indexed as

AedesMosquito VectorsAnimalsCaliforniaGenetics, PopulationGenetic VariationGenome, InsectArbovirusHuman-mediated dispersalHybridizationInvasive speciesMosquitoVector borne diseases

Identifiers

PMID41413441
PMCPMC12752053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.