ArticleClinical rheumatology2026
Comparison of urine protein/creatinine ratio with 24-hour urine protein in ANCA-associated glomerulonephritis.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundUrine protein/creatinine ratio (uPCR) offers practical advantages over 24-hour urine protein (24hUP) for quantifying proteinuria in kidney diseases, but its correlation and agreement with 24hUP (the diagnostic gold standard) remain unvalidated in ANCA-associated glomerulonephritis (AAGN).
methodsThis retrospective study analyzed 164 paired uPCR and 24hUP measurements obtained on the same or following day from 87 AAGN patients. Paired uPCR and 24hUP data were grouped by 24hUP levels: < 500, 500-3500, > 3500 mg/day. Correlation was assessed using Spearman's correlation coefficient (ρ); agreement was evaluated via Intraclass correlation coefficient (ICC) and Concordance correlation coefficient (CCC). Sensitivity and specificity of uPCR percentage changes for predicting 24hUP percentage changes were calculated in 56 patients undergoing inpatient therapy.
resultsThe uPCR strongly correlated with 24hUP across all groups: ρ = 0.616 (< 500 mg/day), 0.794 (500-3500 mg/day), and 0.758 (> 3500 mg/day) (all p < 0.05). However, agreement was suboptimal (ICCs: 0.373, 0.633, 0.458; CCCs: 0.369, 0.635, 0.432.). Percentage changes in uPCR during treatment highly correlated with 24hUP percentage changes (r = 0.886, p < 0.001). A 20% uPCR decrease predicted 20% 24hUP reduction with 97% sensitivity/90% specificity; thresholds of 40% and 60% maintained high accuracy (sensitivity 90, 96%, specificity 93, 95%).
conclusionWhile uPCR correlated strongly with 24hUP in AAGN (especially at 500-3500 mg/day), poor agreement supported retaining 24hUP for initial diagnosis. The uPCR percentage changes reliably reflected therapeutic response with a median interval of 14 days (IQR 8-25), offering a practical alternative for monitoring hospitalized patients. Key Points • The correlation between uPCR and 24hUP in AAGN was strong (particularly at 24hUP levels of 500-3500 mg/day), but the agreement between them was poor. • It was still recommended to retain 24hUP for initial proteinuria quantification in AAGN. • Monitoring of uPCR percentage changes may substitute for 24hUP measurements in assessing renal therapeutic response in AAGN.
Indexed as
Identifiers
41413311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.