Evidence map›Paper›PMID 41413306›Full record

ArticleNpj viruses2025

V

Rameshwar U Kadam, Jarek Juraszek, Boerries Brandenburg, Divita Garg, Xueyong Zhu, Mandy Jongeneelen, Wim B G Schepens, Bart Stoops, Jan Vermond, Wouter Goutier and 6 more

Abstract read
In one paragraph

Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rameshwar U Kadam *Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. rkadam3@its.jnj.com.
Jarek Juraszek *Johnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Boerries BrandenburgJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Divita GargDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Xueyong ZhuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Mandy JongeneelenJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Wim B G SchepensJohnson & Johnson Innovative Medicine, Beerse, Belgium.
Bart StoopsJohnson & Johnson Innovative Medicine, Beerse, Belgium.
Jan VermondJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Wouter GoutierJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Chan TangJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Sven BloklandJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Ronald VogelsJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Robert H E FriesenJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Maria J P van DongenJohnson & Johnson Innovative Medicine, Leiden, The Netherlands.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu.

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Exploiting sites of vulnerability on influenza virusesR56AI117675 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WILSON, IAN A · 2015 to 2015
$836k
Exploiting Vulnerability on Influenza VirusR56AI127371 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WILSON, IAN A · 2017 to 2017
$730k
NIAID NIH HHS R56 AI117675NIAID NIH HHS R56 AI127371NIGMS NIH HHS P41 GM103393NIH HHS R56 AI117675
6 · The paper itself

Abstract

Miniaturizing biologically complex structural motifs to produce synthetic functional mimetics holds significant promise for development of new therapeutic modalities. Here, we demonstrate a unique approach using the key binding loop of the single variable domain of a heavy chain (V

Identifiers

PMID41413306
PMCPMC12714728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.