Evidence map›Paper›PMID 41413300›Full record

ArticleNPJ digital medicine2025

Artificial intelligence-driven multivariate integration for pulmonary arterial pressure prediction in pulmonary hypertension.

Yuxuan Zeng, Gonghao Ling, Haojie Zhang, Wei Cao, Xuan Zheng, Xiaoxian Deng, Lan Lan, Rongqing Sun, Xintian Liu, Lin Tian and 3 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuxuan Zeng *Center of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Gonghao Ling *Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Haojie Zhang *Center of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wei Cao *The Institute of Technological Sciences, Wuhan University, Wuhan, China.
Xuan ZhengCenter of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. xuanzheng@whu.edu.cn.
Xiaoxian DengCenter of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lan LanDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Rongqing SunDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xintian LiuCenter of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lin TianCircle Cardiovascular Imaging Inc., Calgary, AB, Canada.
Haibo XuDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China. xuhaibo@whu.edu.cn.
Ziyu WangCenter of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. zywang@whu.edu.cn.
Gangcheng ZhangCenter of Structural Heart Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. zhanggangcheng@whu.edu.cn.

Funding

Hubei Provincial Key Technology Foundation of China No.2021ACA013National Natural Science Foundation of China No.22327901Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University No. ZNJC202235Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University No.ZNJC202424
6 · The paper itself

Abstract

Reliable machine learning techniques have vast potential in assisting clinical decision-making, including applications in bioinformatics and medical imaging analysis. However, AI-driven medical research is often limited by data scarcity, data quality, and the black-box nature of machine learning models. Thus, there is an urgent need for reliable surrogate models to overcome these challenges, enabling accurate learning from small datasets to guide clinical diagnosis. Here, we conducted a retrospective observational clinical study and proposed a data-driven predictive model that estimates mean pulmonary artery pressure (mPAP) based on individual patient clinical diagnostic features, enabling accurate assessment of pulmonary hypertension. Furthermore, we innovatively incorporate CMR-related features into the disease evaluation framework. Compared to traditional invasive measurement methods, this framework can not only accurately predict a patient's mPAP using easily accessible noninvasive physiological features but also incorporate uncertainty quantification to extract qualitative patterns, aiding clinical diagnosis.

Identifiers

PMID41413300
PMCPMC12816686

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.