ArticleEJNMMI radiopharmacy and chemistry2025
Development of a radio thin-layer chromatography scanner: Design and qualification.
Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundRadiochemical Purity (RCP) assessment is a fundamental quality control parameter in radiopharmaceutical production. Thin-Layer Chromatography (TLC) using a radio-TLC scanner is the most common method employed to determine RCP. However, commercial devices are often expensive and may not be accessible for research environments or budget-constrained laboratories. This study presents the development of a low-cost, open-source radio-TLC scanner utilizing a silicon photomultiplier-based scintillation detector and a linear actuator. The system was designed to scan TLC strips and provide quantitative analysis. Validation for analysis of technetium-99m labeled compounds followed regulatory guidelines and included assessment of background noise, linearity, repeatability, positional accuracy, and comparative analysis against a commercial scanner.
resultsThe system demonstrated good analytical performance, and comparative testing revealed a strong agreement with the results obtained using a commercial radio-TLC scanner.
conclusionThe custom radio-TLC scanner represents a viable and affordable alternative for radiochemical purity assessment in radiopharmaceutical quality control while maintaining compliance with good manufacturing practice standards.
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