Evidence map›Paper›PMID 41413286›Full record

ArticleNature communications2025

β

Sandeep Adhikari, Camille Carrier, Prabhu Raj Joshi, Pankaj Baral

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sandeep AdhikariDepartment of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID http://orcid.org/0009-0003-5069-432X
Camille CarrierDepartment of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID http://orcid.org/0009-0006-1276-2397
Prabhu Raj JoshiDepartment of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID http://orcid.org/0000-0002-7817-2473
Pankaj BaralDepartment of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA. baral@vet.k-state.edu.ORCID https://orcid.org/0000-0002-3902-2368

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Neuronal regulation of tissue-resident macrophage maintenance and polarizationR35GM155117 · NIGMS · KANSAS STATE UNIVERSITY · PI Pankaj Baral · 2024 to 2026
$1.1M
Lung-innervating nociceptor sensory neurons suppresses Ly6chi monocyte responses to promote pneumonic sepsisR21AI186057 · NIAID · KANSAS STATE UNIVERSITY · PI Pankaj Baral · 2025 to 2026
$418k
American Heart Association (American Heart Association, Inc.) 24TPA1294407American Lung Association (Lung Association) 1036079NIAID NIH HHS R21 AI186057NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R35 GM155117U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM155117, R21AI186057, P20GM113117
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is the most common cause of acute bronchiolitis and pneumonia in children under 5 years of age. RSV infection is characterized by lung inflammation, viral expansion, and airway barrier destruction. The crosstalk between neurons and immune and non-immune cells develops from early life onwards. The lungs and airways are densely innervated by sympathetic neurons where they secrete the neurotransmitter noradrenaline (NA) at homeostasis and following injury in adult mice. NA, once secreted into the lungs, can act on immune and non-immune cells through β-adrenergic receptors (β-ARs). However, it is unknown whether NA-β-AR signaling axis regulates antiviral immunity during early-life infections. In a mouse model of neonatal RSV infection, we find that stimulation of adrenergic signaling via β

Indexed as

Receptors, Adrenergic, beta-2Respiratory Syncytial Virus InfectionsAdrenergic beta-2 Receptor AgonistsAnimalsAnimals, NewbornDisease Models, AnimalFemaleHumansLungMaleMiceMice, Inbred C57BLNorepinephrineRespiratory Syncytial VirusesSignal TransductionViral LoadAdrenergic beta-2 Receptor AgonistsNorepinephrineReceptors, Adrenergic, beta-2

Identifiers

PMID41413286
PMCPMC12715253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.