Evidence map›Paper›PMID 41413272›Full record

ArticleScientific reports2025

Notch1 regulates Orai1 and Orai3 expression in breast cancer cells.

Joel Nieto-Felipe, Alvaro Macias-Diaz, Sandra Alvarado, Pedro C Redondo, Vanesa Jimenez-Velarde, Jose J Lopez, Astrid Gorischek, Isaac Jardin, Tarik Smani, Juan A Rosado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joel Nieto-Felipe *Department of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Alvaro Macias-Diaz *Department of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Sandra AlvaradoDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Pedro C RedondoDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Vanesa Jimenez-VelardeDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Jose J LopezDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain. jjlopez@unex.es.
Astrid GorischekDepartment of Medical Physics and Biophysics , Medical University of Graz , Graz, 8010, Austria.
Isaac JardinDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain.
Tarik SmaniGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío/University of Seville/CSIC, Avenida Manuel Siurot s/n, Seville, 41013, Spain.
Juan A RosadoDepartment of Physiology (Cellular Physiology Research Group) Institute of Molecular Pathology Biomarkers (IMPB) , Universidad de Extremadura , Caceres, 10003, Spain. jarosado@unex.es.

Funding

Agencia Estatal de Investigación PID2022-136279NB-C21Agencia Estatal de Investigación PID2022-136279NB-C22Consejería de Economía, Ciencia y Agenda Digital, Junta de Extremadura GR24034Consejería de Economía, Ciencia y Agenda Digital, Junta de Extremadura IB20007
6 · The paper itself

Abstract

Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of intracellular Ca

Indexed as

Breast NeoplasmsCalcium ChannelsGene Expression Regulation, NeoplasticORAI1 ProteinReceptor, Notch1CalciumCell Line, TumorFemaleHumansJagged-1 ProteinSignal TransductionCalciumCalcium ChannelsJAG1 protein, humanJagged-1 ProteinNOTCH1 protein, humanORAI1 ProteinORAI1 protein, humanOrai3 protein, humanReceptor, Notch1Notch1Orai1Orai3Store-operated Ca2+ entry

Identifiers

PMID41413272
PMCPMC12830608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.